The Rise and Fall of Neurotransmitters

There are dozens of neurotransmitters in the human brain. How do neuroscientists decide which transmitters are most important? Are there trends and fashions in neuroscience, such that some transmitters rise and fall in popularity? I searched PubMed for nine different neurotransmitters, and downloaded the 'Results by Year' data to track the number of peer-reviewed papers published each year from 1960 to 2014. The results are very interesting: Here are some of my observations in no parti

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