The Big Bang Theory is a show about scientists, and it bolsters its academic credibility by bringing in guest stars from the world (galaxy?) of science to play themselves, as well as casting actors with graduate degrees to play characters on the show.
I'm not qualified to rank these guest stars
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The Big Bang TheoryNeil deGrasse TysonBill NyeElon MuskDanica McKellarMayim BialikBuzz AldrinStephen Hawking