Simulation studies reveal the role disulfide bonds play in protein folding

(Phys.org)—Diseases like mad cow disease or Alzheimer's are a result of protein mis-folding. Proteins are comprised of an amino acid chain that folds into a three-dimensional structure. According to the Anfinsen Principle, the chemical character of the amino acid chain dictates how the protein folds into its three-dimensional structure. A key component to this folding is the formation of disulfide linkages.

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