Research reveals how succinate dehydrogenase is linked to both tumor and neurodegeneration

Sarah Fendt (VIB-KU Leuven): 'In this project we studied mutations in enzyme succinate dehydrogenase, which are associated with tumors, but also neurodegeneration. This is interesting, because tumors are defined by cells that show sustained proliferation and in this sense sustained fitness, while neurodegeration is defined by cells of impaired fitness. It is surprising that mutations in one and the same enzyme, which all lead to loss of enzyme expression result in two distinct disease...

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