Innate immune adaptor TRIF confers neuroprotection in ALS

Researchers led by Nagoya University report that deficiency of the innate immune adaptor TIR domain-containing adaptor inducing interferon-β (TRIF) significantly shortens survival time and accelerates disease progression of ALS mice. They revealed for the first time that the TRIF pathway is involved in eliminating aberrantly activated astrocytes to maintain the microenvironment surrounding motor neurons in ALS mice. This study provides a clue to develop a new therapeutic approach for...

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