Excess transcription factor Heat Shock Factor 1 can delay embryonic neural migration

Transcription factor Heat Shock Factor 1, which the developing brain releases to shield the vital organ from the ravages of environmental stress, actually can contribute to impairing the embryonic brain when too much Hsf1 is produced, research led by Children's National Health System scientists indicates. While the finding was made in a preclinical model, it raises questions about neural risks for human infants if mothers drink alcohol in the first or second trimester of pregnancy.

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