Epigenetic diversity in childhood cancer

Tumors of the elderly carry many DNA mutations that can influence disease course. In contrast, much fewer genetic variants exist in childhood cancers, leaving their clinical diversity unexplained. This conundrum has now been addressed for Ewing sarcoma: researchers at St. Anna Children's Cancer Research Institute and CeMM Research Center for Molecular Medicine observed unexpected variety in the epigenome of these tumors. This finding, published in Nature Medicine, provides new perspectives...

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