Ancient Treponema pallidum from human remains sheds light on its evolutionary history

The evolutionary history and origin of syphilis, and other treponemal diseases, is a hotly debated topic by scholars. Scholars who theorize syphilis originated in the 'New World' and preceded the 15th century have been in fierce debate with scholars who theorize a multiregional origin followed by the 15th century pandemic spread. Both sides are supported by organic evidence found in contemporary genetic and skeletal remains across the globe.

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